Versus TB-500 / Thymosin beta-4 (43 AA, dose 2-10 mg): TB-500 acts mainly on the cytoskeleton (G-actin sequestration), cell migration and angiogenesis
The Perfect B protocol doses MOTS-c at 5mg (25 units) per injection, once every 5 days, for a total of 4 injections over a 20-day cycle
Animal models are used as they can fill the gap that in vitro models often have, viz, the lack of physiological resemblance
[DOI] [PMC free article] [PubMed] [Google Scholar] Summey BT, Graff RD, Lai T-S, Greenberg CS, Lee GM (2002) Tissue transglutaminase localization and activity regulation in the extracellular matrix of articular cartilage
Studies show that daily oral supplementation is generally well tolerated
However, how quickly you see these results depends on how you take B12